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Dr Guerra reports on evidence that Treg cells are negatively controlled by Nfil3 via inhibition of FOXp3 transcriptio...
  • 17/08/2019
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Dr Guerra reports on evidence that Treg cells are negatively controlled by Nfil3 via inhibition of FOXp3 transcriptio...

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Descripción de Dr Guerra reports on evidence that Treg cells are negatively controlled by Nfil3 via inhibition of FOXp3 transcriptio...

Treg and Th cells are under transcriptional modulation via cytokine mediated control of a Nfil3 protein that serves to block FOXp3 expression.DR Guerra verifies the evidence in the data from a recent paper: Experimental & Molecular Medicine volume 51, Article number: 80 (2019) that demonstrated Inhibition of the TGF-? signaling pathway led to increased Nfil3 expression which blocked Foxp3 transcription via SMAD3.
This is an important contribution to the T lymphocyte literature as it points to the proximal and distal modulation of T cell lineage differentiation, thus focusing attention to potential pharmacotherapeutic and immunoepigenetic mechanisms to control inflammation in diseases such as IBD while simultaneously suggesting strategies to reorganize the T cell profile to destroy tumors.
Dr Daniel J Guerra, Authentic Biochemistry. 17 August 2019.

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