STUDY: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5981249/ A ketogenic diet can: 1 - Decreased reactive oxygen species, (ROS) which are known to contribute to inflammation 2 - Increased adenosine, a natural chemical that is known to fight inflammation and act as a pain reliever 3 - Alleviate IBS (type of inflammation) by a reduction in gluten 4 - Removal of sugar, which releases cytokines, which cause inflammation 5 - If dairy free, can reduce inflammation through removal of lactose intolerance Neurodegenerative diseases: Since 2008 it has become clear that a low carbohydrate diet causes an increase of KETONE BODIES serum levels, paralleled by a reduction in several inflammatory parameters, and that KD allows neuroprotection for brain injuries and neurodegenerative diseases A randomized controlled dietary intervention trial was done on 40 overweight subjects aged 18–55 years, fed with a diet very low in carbohydrate or an isocaloric diet low in fat for 12 weeks. Subjects fed with KD developed a mild ketosis and showed weight loss, decreased adiposity, and an improved glycaemic control as well as an improved insulin sensitivity. Both diets significantly decreased the concentration of several serum inflammatory markers, but there was an overall greater anti-inflammatory effect associated with KD The ketogenic diet showed a reduction in TNF-alpha, interleukin-8 (IL-8), (MCP-1), (PAI-1), (ICAM-1), while these markers showed a little change in the subjects fed with a low fat diet. This suggests that it is the macronutrient composition, not the weight loss or the caloric reduction the real responsible for the anti-inflammatory activity Several neurodegenerative diseases are interconnected by shared neurotoxic mechanisms related to inflammatory mechanisms such as cytokine release, neurotrophin synthesis inhibition, release of NO and CO, which are potentially harmful to surrounding tissues In response, the cells provide endogenous mechanisms tending to neutralize the molecules responsible for inflammatory damage A winning strategy to attempt to block neuroinflammation may consist in the enhancement of endogenous anti-inflammatory programs. One of the most promising approaches seems to be the ketogenic diet The ketogenic diet has shown to decrease the production of Amyloid Precursor Protein (APP) and therefore the ?amyloid peptide A ketogenic diet can activate peroxisome proliferator-activated receptor gamma (PPAR?) which decreases systemic inflammation ?HB, one of the main substances detected in the blood after following a ketogenic diet, is able to cross the BBB thanks to the specific expression of its transporter MCT1 on endothelial cells. But after its entrance into the brain, ?-hydroxybutyrate (?HB) not only provides energy but activates the receptor hydroxy-carboxylic acid receptor 2 (HCA2), which lowers neuroinflammation The activation of HCA2 by ketogenic diet was shown to induce a neuroprotective phenotype in bone-marrow derived macrophages that infiltrate the brain ?HB mediated the inhibition of NLRP3 inflammasome in lipopolysaccharides (LPS)-stimulated human monocytes leading to a reduced production of interleukin-1beta (IL-1beta) and interleukin-18 (IL-18) without significantly affecting tumour necrosis factor-alpha (TNF-alpha) levels Which Foods Cause The Most Inflammation: Processed foods that are packaged and refined. High-GI foods Refined seed oils, corn, safflower, soybean oils Dairy Coffee and alcohol
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